![]() Due to the impact of early intervention the challenge of distinguishing early AD from normal ageing has received increasing attention. The diagnosis is difficult to make and is often made over a longer period of time using a combination of neuropsychological tests, and structural and functional imaging. R.Īlzheimer's disease (AD) is a neurodegenerative disorder that causes cortical atrophy and impaired cognitive functions. All rights reserved.Įarly detection of AD using cortical thickness measurements The ASI-based metrics introduced in our work allow direct translational comparison to in vivo animal models, as well as hold promise for implementation as a functional developmental biomarker in future research on human neonates. These findings provide evidence that early cortical activity is increasingly synchronized across the neocortex. Second, there were significant spatial gradients in the synchrony in fronto-occipital and left-to-right directions. First, we observed a robust and statistically significant increase in ASI in all cortical areas. The developmental correlations of ASI were computed for individual EEG signals as well as anatomically and mathematically defined spatial subgroups. ![]() ![]() We recorded scalp EEG from altogether 22 premature infants at post-menstrual age between 30 and 44 weeks, and the early cortical synchrony was quantified using recently introduced activation synchrony index (ASI). Here, we tested the hypothesis that the early intermittent cortical activations seen in the human scalp EEG show a clear developmental course during the last trimester of pregnancy, the period of intensive growth of cortico- cortical connections. Yet, the early development of the large scale synchrony in cortical activations is unknown. Koolen, N Dereymaeker, A Räsänen, O Jansen, K Vervisch, J Matic, V Naulaers, G De Vos, M Van Huffel, S Vanhatalo, SĮarly intermittent cortical activity is thought to play a crucial role in the growth of neuronal network development, and large scale brain networks are known to provide the basis for higher brain functions. Early development of synchrony in cortical activations in the human.
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